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James W Paxton Selected Research

N- (2- (dimethylamino)ethyl)- 2,6- dimethyl- 1- oxo- 1,2- dihydroxybenzo(b)- 1,6- naphthyridine- 4- carboxamide

7/2014Selective cellular uptake and retention of SN 28049, a new DNA-binding topoisomerase II-directed antitumor agent.
11/2013Tumour tissue selectivity in the uptake and retention of SN 28049, a new topoisomerase II-directed anticancer agent.
7/2012Comparison of a homologous series of benzonaphthyridine anti-cancer agents in mice: divergence between tumour and plasma pharmacokinetics.
11/2008Development and validation of a liquid chromatography-mass spectrometry (LC-MS) assay for the determination of the anti-cancer agent N-[2-(dimethylamino)ethyl]-2,6-dimethyl-1-oxo-1,2-dihydrobenzo[b]-1,6-naphthyridine-4-carboxamide (SN 28049).

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James W Paxton Research Topics

Disease

19Neoplasms (Cancer)
02/2015 - 01/2002
8Breast Neoplasms (Breast Cancer)
02/2015 - 05/2006
5Adenocarcinoma
07/2021 - 01/2002
4Pancreatic Neoplasms (Pancreatic Cancer)
07/2021 - 09/2011
2Necrosis
08/2002 - 01/2002
1Carcinoma (Carcinomatosis)
07/2014
1Poisoning
11/2013
1Chronic Disease (Chronic Diseases)
06/2012
1Vascular System Injuries
06/2009
1Lung Neoplasms (Lung Cancer)
02/2009
1Fetal Growth Retardation (Intrauterine Growth Retardation)
11/2007
1Teratogenesis
02/2006
1Colonic Neoplasms (Colon Cancer)
01/2005
1Tremor (Tremors)
08/2002
1Squamous Cell Carcinoma (Epidermoid Carcinoma)
08/2002
1Cognitive Dysfunction
08/2002
1Cachexia
01/2002
1Prostatic Neoplasms (Prostate Cancer)
01/2002

Drug/Important Bio-Agent (IBA)

16Pharmaceutical PreparationsIBA
03/2013 - 01/2002
12vadimezanIBA
06/2009 - 01/2002
10Proteins (Proteins, Gene)FDA Link
02/2015 - 11/2002
6ATP-Binding Cassette Transporters (ABC Transporters)IBA
02/2015 - 02/2006
5XenobioticsIBA
02/2015 - 11/2010
4CurcuminIBA
07/2021 - 09/2011
4PhytochemicalsIBA
02/2015 - 11/2010
4N- (2- (dimethylamino)ethyl)- 2,6- dimethyl- 1- oxo- 1,2- dihydroxybenzo(b)- 1,6- naphthyridine- 4- carboxamideIBA
07/2014 - 11/2008
3GemcitabineFDA Link
07/2021 - 01/2016
3Member 1 Subfamily B ATP Binding Cassette TransporterIBA
02/2015 - 05/2006
3Type II DNA Topoisomerases (Topoisomerase II)IBA
07/2014 - 02/2009
3EnzymesIBA
11/2013 - 07/2002
3Thalidomide (Thalomid)FDA Link
01/2005 - 01/2002
2Liposomes (Liposome)IBA
07/2021 - 01/2016
2cyclohexanoneIBA
05/2017 - 02/2015
2Subfamily B ATP Binding Cassette TransporterIBA
03/2013 - 05/2006
2Chlorambucil (Leukeran)FDA Link
02/2010 - 08/2008
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
04/2007 - 08/2002
2GlucuronidesIBA
04/2005 - 09/2004
1UridineIBA
05/2017
1Equilibrative Nucleoside Transporter 1IBA
05/2017
1Multidrug Resistance-Associated ProteinsIBA
02/2015
1multidrug resistance-associated protein 1IBA
02/2015
1PoisonsIBA
07/2014
1DNA (Deoxyribonucleic Acid)IBA
07/2014
1falcarinolIBA
01/2014
1falcarindiolIBA
01/2014
1FlavonoidsIBA
03/2013
1GlycosidesIBA
03/2013
1A-Form DNA (A-DNA)IBA
07/2012
1Monoclonal AntibodiesIBA
09/2011
1Fluorouracil (Carac)FDA LinkGeneric
09/2011
1SalicylatesIBA
06/2009
1Ibuprofen (Motrin)FDA LinkGeneric
06/2009
1Celecoxib (Celebrex)FDA Link
06/2009
1Diclofenac (SR 38)FDA LinkGeneric
06/2009
1rofecoxib (Vioxx)FDA Link
06/2009
1ProstaglandinsIBA
06/2009
1Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
06/2009
1asulacrineIBA
02/2009
1Adenosine Triphosphate (ATP)IBA
11/2007
1Messenger RNA (mRNA)IBA
04/2007
1InterleukinsIBA
04/2007
1Serotonin (5 Hydroxytryptamine)IBA
08/2002
1Immunologic Factors (Immunomodulators)IBA
08/2002
1Drug CombinationsIBA
08/2002
1Nitric Oxide (Nitrogen Monoxide)FDA Link
08/2002
1Biological ProductsIBA
08/2002
1CytokinesIBA
08/2002
1dimethylaniline monooxygenase (N-oxide forming) (flavin-containing monooxygenase)IBA
07/2002
1Complementary DNA (cDNA)IBA
07/2002
1Cytochrome P-450 Enzyme System (Cytochrome P450)IBA
02/2002
1Uridine Diphosphate (UDP)IBA
02/2002
1Hypnotics and Sedatives (Sedatives)IBA
01/2002
1Cyclophosphamide (Cytoxan)FDA LinkGeneric
01/2002

Therapy/Procedure

4Drug Therapy (Chemotherapy)
09/2011 - 09/2002
2Therapeutics
06/2009 - 08/2002
1Intravenous Infusions
08/2002